Research Interests

Biomedical imaging, image reconstruction, digital tomosynthesis, image quality analysis, signal and image processing, simulation and computing.

Education

Ph. D, Duke University, Durham, North Carolina, USA

M.S, B.S., Shanghai Jiao Tong University, Shanghai, China

Class Taught

ECE 467/567 Biomedical Imaging, Fall 2008

ECE 493/593-001 Introduction to Biomedical Imaging, Spring 2008

ECE 493/593-002 Introduction to Biomedical Imaging, Fall 2007

ECE 592-719 Independent Study Section, Fall 2007

Honors/Awards

Predoctoral Traineeship Award, U.S. Department of Defense Congressionally Directed Medical Research Programs

Conference Travel Fellowship, Duke University, 2006

Conference Travel Fellowship, Duke University, 2005

Teaching training program fellowship, Duke University, 2002

National Excellent Graduate Student Fellowship, China, 1999

Excellent Student Awards, People Scholarships (multiple times), Excellent Student Council Activities, China, 1993-2000

Copper Medal of Chinese Hope Cup National Mathematics Competition, 1992

Silver Medal of Chinese Hope Cup National Mathematics Competition, 1991

Affiliation

Full member, Sigma Xi - The Scientific Research Society

Member, SPIE - The International Society for Optical Engineering

Full member, AAPM - The American Association of Physicists in Medicine (in processing)

Invited Lectures

Feb. 23, 2005 “Impulse response analysis of breast tomosynthesis reconstruction algorithms”, invited by Medical Physics Graduate Program, Duke University Medical Center.

Feb. 9, 2006 “Gaussian frequency blending algorithm with matrix inversion tomosynthesis (MITS) and filtered back projection (FBP) for better digital breast tomosynthesis reconstruction”, invited by Medical Physics Graduate Program. Duke University Medical Center.

May 7, 2007 “Digital tomosynthesis (DTS): a novel imaging technique for improving breast cancer detection -- image reconstruction & optimization”, invited by Prof. Otto Zhou, Department of Physics & Astronomy, The University of North Carolina at Chapel Hill.

Nov. 9, 2007 “Digital Breast Tomosynthesis (DTS): A Novel Imaging Technique to Improve Early Breast Cancer Detection -- Implementation, Comparison and Optimization”, invited by Engineering Seminars, Southern Illinois University Carbondale.

        July 2008          Invited talk in planning, invited by Simmons Cooper Cancer Institute seminar, Southern Illinois University Springfield.

Paper Review and Editorial Work

Guest Editor, International journal of Functional Informatics and Personalised Medicine (IJFIPM)

Program Committee, paper reviewer, IEEE 7^th International Symposium on Bioinformatics and BioEngineering

Paper reviewer, 2007 ASME International Mechanical Engineering Congress and Exposition

Research Grants

Co-Principal Investigator, NIH grant (submitted)

Principal Investigator, SIUC start up grant

Principal Investigator, Department of Defense CDMRP: Optimization and Comparison of Different Digital Mammographic Tomosynthesis Reconstruction Methods, April 2006 - September 2007 (completed)

Key personnel, NIH/NCI: digital breast tomosynthesis collaborated with Siemens Medical Solutions, 2003-2006 (completed); digital chest tomosynthesis collaborated with GE Healthcare, 2001-2003 (completed)

Publications

Ph.D. dissertation:

Y. Chen, Digital breast tomosynthesis (DBT) - a novel imaging technology to improve early breast cancer detection: implementation, comparison and optimization, Duke University, 2007.

Publications

[1] Y. Chen, J. Y. Lo, and J. T. Dobbins III., Importance of point-by-point back projection (BP) correction for isocentric motion in digital breast tomosynthesis: Relevance to morphology of microcalcifications, Med. Phys. 34(10), 3885-3892 (2007).

[2] Y. Chen, J. Y. Lo, and J. T. Dobbins III., Impulse response and modulation transfer function analysis for shift-and-add and back projection image reconstruction algorithms in digital breast tomosynthesis (DBT), The International Journal of Functional Informatics and Personalised Medicine (IJFIPM), (2008).

[3] Y. Chen, J. Y. Lo, J. T. Dobbins III, A Comparison between Traditional Shift-and add (SAA) and Point-by-point Back Projection (BP) – Relevance to Morphology of Microcalcifications for Isocentric Motion in Digit Breast Tomosynthesis (DBT), Proceedings of IEEE-Bioinformatics & Bioengineering, Vol. I, 563-569 (2007).

[4] Y. Chen, J. Y. Lo, N. T. Ranger, E. Samei, J. T. Dobbins III, Methodology of NEQ(f) analysis for optimization and comparison of digital breast tomosynthesis acquisition techniques and reconstruction algorithms, Proc. SPIE 6510, 65101-I, (2007).

[5] Y. Chen, J. Y. Lo, and J. T. Dobbins III, NEQ (f) analysis of different breast tomosynthesis reconstruction algorithms and imaging acquisition techniques, in preparation for Med. Phys., 2007.

[6] Y. Chen, J. Y. Lo, J. A. Baker, and J. T. Dobbins III, Gaussian Frequency Blending (GFB) algorithm for digital breast tomosynthesis reconstruction, in preparation for Med. Phys., 2007.

[7] E. Samei, N. T. Ranger, J. T. Dobbins III, and Y. Chen, Intercomparison of methods for image quality characterization: I. modulation transfer function, Med. Phys. 33 (5), 1454-1465 (2006).

[8] J. T. Dobbins III, E. Samei, N. T. Ranger, and Y. Chen, Intercomparison of methods for image quality characterization: II. noise power spectrum, Med. Phys. 33 (5), 1466-1475 (2006).

[9] Y. Chen, J. Y. Lo, J. A. Baker, J. T. Dobbins III, Gaussian frequency blending algorithm with Matrix Inversion Tomosynthesis (MITS) and Filtered Back Projection (FBP) for better digital breast tomosynthesis reconstruction, Proc. SPIE 6142, 122-130 (2006).

[10] Y. Chen, J. Y. Lo, J. A. Baker, J. T. Dobbins III, Noise power spectrum analysis for several digital breast tomosynthesis reconstruction algorithms, Proc. SPIE 6142, 1677-1684 (2006).

[11] Y. Chen, J. Y. Lo, J. T. Dobbins III, Two-dimensional Shift-And-Add Algorithm for Digital Breast Tomosynthesis Reconstruction, Med. Phys. 33 (6), 2001 (2006).

[12] Y. Chen, J. Y. Lo, J. T. Dobbins III, Impulse response analysis for several digital tomosynthesis mammography reconstruction algorithms, Proc. SPIE 5745, 541-549 (2005).

[13] M Bissonnette, M Hansroul, E Masson, S Savard, S Cadieux, P Warmoes, D Gravel, J Agopyan, B Polischuk, W Haerer, T Mertelmeier, J Lo, Y Chen, J Dobbins, J Jesneck, S Singh, Digital breast tomosynthesis using an amorphous selenium flat panel detector, Proc. SPIE 5745, 529-540 (2005).

[14] Y. Chen, J. Y. Lo, J. T. Dobbins III, Matrix Inversion Tomosynthesis (MITS) of the Breast: Preliminary Results, Radiological Society of North America (RSNA) 90^th Scientific Assembly, Chicago, IL, Dec. 2004.

[15] Y. Chen, X. Xiao, J. Jiang, W. Wang, F. Sun, High intensity focused ultrasound transducer and its application for therapy, Technical Acoustics (in Chinese), 19(3), 158-160 (2000).

[16] Y. Chen, P. Yu, Photoelectric technique for the automatic non-destruction test of the inner surface, Optoelectronic Technology (in Chinese), 19(4), 265-269 (1999).

Presentations

[1] Y. Chen, J. Y. Lo, J. T. Dobbins III, A Comparison between Traditional Shift-and add (SAA) and Point-by-point Back Projection (BP) – Relevance to Morphology of Microcalcifications for Isocentric Motion in Digit Breast Tomosynthesis (DBT), Proceedings of IEEE-Bioinformatics & Bioengineering, Boston, USA, Oct 2007.

[2] Y. Chen, J. Y. Lo, N. T. Ranger, E. Samei, J. T. Dobbins III, Methodology of NEQ(f) analysis for optimization and comparison of digital breast tomosynthesis acquisition techniques and reconstruction algorithms, International Society for Optical Engineering (SPIE) Medical Imaging conference, San Diego, California, USA, Feb 2007.

[3] Y. Chen, J. Y. Lo, J. T. Dobbins III, Two-dimensional Shift-And-Add Algorithm for Digital Breast Tomosynthesis Reconstruction, American Association of Physicists in Medicine (AAPM) 48^th Annual Meeting, Orlando, Florida, USA, Aug 2006.

[4] Y. Chen, J. Y. Lo, J. A. Baker, J. T. Dobbins III, Gaussian frequency blending algorithm with Matrix Inversion Tomosynthesis (MITS) and Filtered Back Projection (FBP) for better digital breast tomosynthesis reconstruction, International Society for Optical Imaging (SPIE) Physics of Medical Imaging conference, San Diego, California, USA, Feb 2006.

[5] Y. Chen, J. Y. Lo, J. A. Baker, J. T. Dobbins III, Noise power spectrum analysis for several digital breast tomosynthesis reconstruction algorithms, International Society for Optical Imaging (SPIE) Physics of Medical Imaging conference, San Diego, California, USA, Feb 2006.

[6] Y. Chen, J. Y. Lo, J. T. Dobbins III, Impulse response analysis for several digital tomosynthesis mammography reconstruction algorithms, International Society for Optical Imaging (SPIE) Physics of Medical Imaging conference, San Diego, California, USA, Feb 2005.

[7] Y. Chen, J. Y. Lo, J. T. Dobbins III, Matrix Inversion Tomosynthesis (MITS) of the Breast: Preliminary Results, Radiological Society of North America (RSNA) 90^th Scientific Assembly, Chicago, IL, USA, Dec. 2004.