Research Interests

Biomedical imaging, digital tomosynthesis, image reconstruction, image quality analysis, signal and image processing, instrumentation, simulation and computing.

Education

Ph. D, Duke University, Durham, North Carolina, USA

M.S, B.S., Shanghai Jiao Tong University, Shanghai, China

Honors/Awards

Research Scholarly and Creative Activity Awards, Southern Illinois University, Carbondale, 2008

Conference Travel Fellowship, Duke University, 2006

Predoctoral Traineeship Award, U.S. Department of Defense Congressionally Directed Medical Research Programs, 2005

Conference Travel Fellowship, Duke University, 2005

Teaching training program fellowship, Duke University, 2002

Fellowship of National Excellence, China, 1999

Excellent Student Awards, People Fellowships (multiple times), Excellent Student Council Activities, Shanghai Jiao Tong University, China, 1993-2000

Copper Medal of Chinese Hope Cup National Mathematics Competition, China, 1992

Silver Medal of Chinese Hope Cup National Mathematics Competition, China 1991

Research Grants

Co-Principal Investigator, U.S. National Institutes of Health (NIH) /NCI R01 grant (PI: UNC)

Principal Investigator, Research Scholarly and Creative Activity Awards, SIUC UPWA

Co-Principal Investigator, Graduate Technology Enhancement, SIUC (PI: Weng, SIUC)

Principal Investigator, SIUC start up grant

Principal Investigator, U.S. Department of Defense CDMRP, April 2006 - September 2007 (completed)

Key personnel, U.S. National Institutes of Health (NIH) /NCI R01: digital breast tomosynthesis collaborated with Siemens Medical Solutions, 2003-2006 (completed); digital chest tomosynthesis collaborated with GE Healthcare, 2001-2003 (completed)

Affiliation

Full member, Sigma Xi - The Scientific Research Society

Member, SPIE - The International Society for Optical Engineering

Full member, AAPM - The American Association of Physicists in Medicine

Invited Talks/Lectures

Feb. 23, 2005 “Impulse response analysis of breast tomosynthesis reconstruction algorithms”, invited by Medical Physics Graduate Program, Duke University Medical Center.

Feb. 9, 2006 “Gaussian frequency blending algorithm with matrix inversion tomosynthesis (MITS) and filtered back projection (FBP) for better digital breast tomosynthesis reconstruction”, invited by Medical Physics Graduate Program. Duke University Medical Center.

May 7, 2007 “Digital tomosynthesis (DTS): a novel imaging technique for improving breast cancer detection -- image reconstruction & optimization”, invited by Prof. Otto Zhou, Department of Physics & Astronomy, The University of North Carolina at Chapel Hill.

Nov. 9, 2007 “Digital Breast Tomosynthesis (DTS): A Novel Imaging Technique to Improve Early Breast Cancer Detection -- Implementation, Comparison and Optimization”, invited by Engineering Seminars, Southern Illinois University Carbondale.

        July 30, 2008      Invited talk in planning, invited by Simmons Cooper Cancer Institute seminar, Simmons Cooper Cancer Institute, SIUMed.

Paper Review and Editorial Work

Guest Editor, Editorial Board Member, 4^th issue, International journal of Functional Informatics and Personalised Medicine (IJFIPM)

Paper reviewer, Medical Physics (impact factor 3.2)

Paper reviewer, Academic Radiology (impact factor 2.1)

Paper reviewer, IEEE transactions on medical imaging (impact factor 3.3)

Paper reviewer, International Journal of Computational Biology and Drug Design

Program Committee, paper reviewer, IEEE 7^th International Symposium on Bioinformatics and BioEngineering

Paper reviewer, 2007 ASME International Mechanical Engineering Congress and Exposition

Paper reviewer, Scientific Journals International (SJI)

Paper reviewer, American Association of Physicists in Medicine (AAPM) Annual Meeting

Class Taught

Spring 2009

ECE 468 Digital Signal Processing, Spring 2009

ECE 467/567 Biomedical Imaging, Spring 2009

Fall 2008

ECE 467/567/BME 532 Biomedical Imaging, Fall 2008

BME 597 Biomedical Engineering Research Ethics, Fall 2008

ECE 592-719 Independent Study Section, Fall 2007

Spring 2008:

ECE 493/593-001 Introduction to Biomedical Imaging, Spring 2008

Fall 2007:

ECE 493/593-002 Introduction to Biomedical Imaging, Fall 2007

ECE 592-719 Independent Study Section, Fall 2007

Students

Ph.D. advisor for: Weihua Zhou

M.S. advisor for: Apuroop Balla, Cleveland Rayford, Pooja Yelsangikar

Ph.D. committee member for: Matt Kelsey, Yonglian Wang, Muhammad R. Khan, Srinivas Kota

M.S. committee member for: Swetha Murali

University Services

Course Coordinator for ECE 467/567 Introduction to Biomedical Imaging, 2007-present
Ph.D. Committee of Department of Electrical and Computer Engineering, 2007 - present.
Course Review Committee for ECE 592 Independent Study, 2008
Commencement Ceremony Marshal, 2008 Summer

· College Student Affairs Committee, College of Engineering, 2009

Selected Publications

A. Refereed full-length Journal and Proceedings

[1] Y. Chen, J. Y. Lo, and J. T. Dobbins III., Importance of point-by-point back projection (BP) correction for isocentric motion in digital breast tomosynthesis: Relevance to morphology of microcalcifications, Med. Phys. 34(10), 3885-3892 (2007). (Impact factor: 3.2)

[2] E. Samei, N. T. Ranger, J. T. Dobbins III, and Y. Chen, Intercomparison of methods for image quality characterization: I. modulation transfer function, Med. Phys. 33 (5), 1454-1465 (2006). (Impact factor: 3.2)

[3] J. T. Dobbins III, E. Samei, N. T. Ranger, and Y. Chen, Intercomparison of methods for image quality characterization: II. noise power spectrum, Med. Phys. 33 (5), 1466-1475 (2006). (Impact factor: 3.2)

[4] Y. Chen, J. Y. Lo, and J. T. Dobbins III., Impulse response and modulation transfer function analysis for shift-and-add and back projection image reconstruction algorithms in digital breast tomosynthesis (DBT), The International Journal of Functional Informatics and Personalized Medicine (IJFIPM), Vol. 1(2), 189-204 (2008).

[5] Weihua Zhou, Apuroop Balla, Y. Chen, “Tomosynthesis reconstruction using an accelerated expectation maximization algorithm with novel data structure based on sparse matrix ray-tracing method,” International Journal of Functional Informatics and Personalised Medicine, Vol. 1(4), 16-27 (2008). (Corresponding Author)

[6] Y. Chen, W. Zhou, G. Yang, J. Lu and O. Zhou, “Breast tomosynthesis reconstruction with a multi-beam x-ray source” SPIE Physics of Medical Imaging conference Proceedings, Feb. 2009.

[7] Y. Chen, J. Y. Lo, J. T. Dobbins III, A Comparison between Traditional Shift-and add (SAA) and Point-by-point Back Projection (BP) – Relevance to Morphology of Microcalcifications for Isocentric Motion in Digit Breast Tomosynthesis (DBT), Proceedings of IEEE-Bioinformatics & Bioengineering, Vol. I, 563-569 (2007).

[8] Y. Chen, J. Y. Lo, N. T. Ranger, E. Samei, J. T. Dobbins III, Methodology of NEQ(f) analysis for optimization and comparison of digital breast tomosynthesis acquisition techniques and reconstruction algorithms, Proc. SPIE 6510, 65101-I, (2007).

[9] Y. Chen, J. Y. Lo, J. A. Baker, J. T. Dobbins III, Gaussian frequency blending algorithm with Matrix Inversion Tomosynthesis (MITS) and Filtered Back Projection (FBP) for better digital breast tomosynthesis reconstruction, Proc. SPIE 6142, 122-130 (2006).

[10] Y. Chen, J. Y. Lo, J. A. Baker, J. T. Dobbins III, Noise power spectrum analysis for several digital breast tomosynthesis reconstruction algorithms, Proc. SPIE 6142, 1677-1684 (2006).

[11] Y. Chen, J. Y. Lo, J. T. Dobbins III, Impulse response analysis for several digital tomosynthesis mammography reconstruction algorithms, Proc. SPIE 5745, 541-549 (2005).

[12] M Bissonnette, M Hansroul, E Masson, S Savard, S Cadieux, P Warmoes, D Gravel, J Agopyan, B Polischuk, W Haerer, T Mertelmeier, J Lo, Y Chen, J Dobbins, J Jesneck, S Singh, Digital breast tomosynthesis using an amorphous selenium flat panel detector, Proc. SPIE 5745, 529-540 (2005).

[13] Y. Chen, X. Xiao, J. Jiang, W. Wang, F. Sun, High intensity focused ultrasound transducer and its application for therapy, Technical Acoustics (in Chinese), 19(3), 158-160 (2000).

[14] Y. Chen, P. Yu, Photoelectric technique for the automatic non-destruction test of the inner surface, Optoelectronic Technology (in Chinese), 19(4), 265-269 (1999).

B. Journal papers in preparation:

[15] Y. Chen, J. Y. Lo, and J. T. Dobbins III, NEQ (f) analysis of different breast tomosynthesis reconstruction algorithms and imaging acquisition techniques, in preparation for Med. Phys.

[16] Y. Chen, J. Y. Lo, J. A. Baker, and J. T. Dobbins III, Gaussian Frequency Blending (GFB) algorithm for digital breast tomosynthesis reconstruction, in preparation for Med. Phys.

C. Conference Abstracts

[17] Y. Chen, W. Zhou, X. Qian, J. Lu and O. Zhou, “Breast tomosynthesis reconstruction and optimization with a multi-beam x-ray source: preliminary results,” Tomosynthesis Imaging Symposium 2009: Frontiers in Research and Clinical Applications.

[18] Y. Chen, J. Y. Lo, and J. T. Dobbins III., “Comparison and optimization of digital breast tomosynthesis image reconstruction algorithms and imaging acquisition parameters”, Proceedings of Department of Defense Breast Cancer Research Program Era of Hope Meeting, 295, 2008.

[19] Y. Chen, J. Y. Lo, J. T. Dobbins III, Two-dimensional Shift-And-Add Algorithm for Digital Breast Tomosynthesis Reconstruction, Med. Phys. 33 (6), 2001 (2006).

[20] Y. Chen, J. Y. Lo, J. T. Dobbins III, Matrix Inversion Tomosynthesis (MITS) of the Breast: Preliminary Results, Radiological Society of North America (RSNA) 90^th Scientific Assembly, Chicago, IL, Dec. 2004.

D. Ph.D. dissertation:

[21] Y. Chen, Digital breast tomosynthesis (DBT) - a novel imaging technology to improve early breast cancer detection: implementation, comparison and optimization, Duke University, 2007 (Available upon request).

International Conference Presentations

[1] Y. Chen, W. Zhou, X. Qian, J. Lu and O. Zhou, “Breast tomosynthesis reconstruction and optimization with a multi-beam x-ray source: preliminary results,” Tomosynthesis Imaging Symposium 2009: Frontiers in Research and Clinical Applications, Durham, NC, USA, May 2009.

[2] Y. Chen, W. Zhou, G. Yang, J. Lu and O. Zhou, “Breast tomosynthesis reconstruction with a multi-beam x-ray source”, SPIE Physics of Medical Imaging conference, Orlando, FL, USA, Feb. 2009.

[3] Y. Chen, J. Y. Lo, and J. T. Dobbins III., “Comparison and optimization of digital breast tomosynthesis image reconstruction algorithms and imaging acquisition parameters”, Department of Defense Breast Cancer Research Program Era of Hope Meeting, Baltimore, MD, USA, June 2008.

[4] Y. Chen, J. Y. Lo, J. T. Dobbins III, A Comparison between Traditional Shift-and add (SAA) and Point-by-point Back Projection (BP) – Relevance to Morphology of Microcalcifications for Isocentric Motion in Digit Breast Tomosynthesis (DBT), IEEE-Bioinformatics & Bioengineering Conference, Boston, USA, Oct 2007.

[5] Y. Chen, J. Y. Lo, N. T. Ranger, E. Samei, J. T. Dobbins III, Methodology of NEQ(f) analysis for optimization and comparison of digital breast tomosynthesis acquisition techniques and reconstruction algorithms, International Society for Optical Engineering (SPIE) Medical Imaging conference, San Diego, California, USA, Feb 2007.

[6] Y. Chen, J. Y. Lo, J. T. Dobbins III, Two-dimensional Shift-And-Add Algorithm for Digital Breast Tomosynthesis Reconstruction, American Association of Physicists in Medicine (AAPM) 48^th Annual Meeting, Orlando, Florida, USA, Aug 2006.

[7] Y. Chen, J. Y. Lo, J. A. Baker, J. T. Dobbins III, Gaussian frequency blending algorithm with Matrix Inversion Tomosynthesis (MITS) and Filtered Back Projection (FBP) for better digital breast tomosynthesis reconstruction, International Society for Optical Imaging (SPIE) Physics of Medical Imaging conference, San Diego, California, USA, Feb 2006.

[8] Y. Chen, J. Y. Lo, J. A. Baker, J. T. Dobbins III, Noise power spectrum analysis for several digital breast tomosynthesis reconstruction algorithms, International Society for Optical Imaging (SPIE) Physics of Medical Imaging conference, San Diego, California, USA, Feb 2006.

[9] Y. Chen, J. Y. Lo, J. T. Dobbins III, Impulse response analysis for several digital tomosynthesis mammography reconstruction algorithms, International Society for Optical Imaging (SPIE) Physics of Medical Imaging conference, San Diego, California, USA, Feb 2005.

[10] Y. Chen, J. Y. Lo, J. T. Dobbins III, Matrix Inversion Tomosynthesis (MITS) of the Breast: Preliminary Results, Radiological Society of North America (RSNA) 90^th Scientific Assembly, Chicago, IL, USA, Dec. 2004.